Psychotic issues are widespread and disabling psychological circumstances. The relative significance of immune-related mechanisms in psychotic issues stays topic of debate. Right here, we current a large-scale retrospective research of blood and cerebrospinal fluid (CSF) immune cell profiles of psychosis spectrum sufferers. We carried out primary CSF evaluation and multi-dimensional movement cytometry of CSF and blood cells from 59 sufferers with main psychotic issues (F20, F22, F23, and F25) compared to inflammatory (49 RRMS and 16 NMDARE sufferers) and non-inflammatory controls (52 IIH sufferers).
We replicated the recognized growth of monocytes within the blood of psychosis spectrum sufferers, that we recognized to preferentially have an effect on classical monocytes. Within the CSF, we discovered a relative shift from lymphocytes to monocytes, elevated protein ranges, and proof of blood-brain barrier disruption in psychosis. Actually, these CSF options confidently distinguished autoimmune encephalitis from psychosis regardless of comparable (preliminary) medical options.
We then constructed machine studying fashions incorporating blood and CSF parameters and demonstrated their superior capacity to distinguish psychosis from non-inflammatory controls in comparison with particular person parameters. Multi-dimensional and multi-compartment immune cell signatures can thus help the prognosis of psychosis spectrum issues with the potential to speed up prognosis and initiation of remedy.
Growth of a Particular Anti-capsid Antibody- and Magnetic Bead-Primarily based Immunoassay to Detect Human Norovirus Particles in Stool Samples and Spiked Mussels through Circulate Cytometry
Human noroviruses impose a substantial well being burden globally. Right here, a movement cytometry strategy designed for his or her detection in organic waste and meals samples was developed utilizing antibody-coated magnetic beads. Antipeptide antibodies in opposition to murine norovirus and numerous human norovirus genotypes had been generated for seize and coated onto magnetic beads. A movement cytometry assay was then carried out to detect bead-bound human norovirus GI.three in affected person stool samples and in norovirus-spiked mussel digestive tissues.
The detection restrict for stool samples was 105 gc/mL, thus bettering detection limits of commercially accessible norovirus prognosis fast kits of 100-fold; the detection restrict in spiked mussels nevertheless was ten-fold increased than in stool samples. Additional assays confirmed a lower in fluorescence depth for heat- or UV-inactivated virus particles. General, we exhibit the appliance of a movement cytometry strategy for direct detection of small non-enveloped virus particles comparable to noroviruses. An adaptation of the expertise to routine diagnostics has the potential to contribute a fast and delicate device to norovirus outbreak investigations. Additional enhancements to the tactic, notably lowering the detection restrict of the strategy, could permit the evaluation of naturally contaminated meals and environmental samples.
Single-reaction multi-antigen serological take a look at for complete analysis of SARS-CoV-2 sufferers by movement cytometry
Right here we describe a brand new, easy, extremely multiplexed serological take a look at that generates a extra full image of seroconversion than single antigen-based assays. Circulate cytometry is used to detect a number of immunoglobulin isotypes binding to 4 SARS-CoV-2 antigens: the Spike glycoprotein, its RBD fragment (the key goal for neutralising antibodies), the nucleocapsid protein and the principle cysteine-like protease in a single response. Till now, most diagnostic serological assessments measured antibodies to just one antigen and in some laboratory-confirmed sufferers no SARS-CoV-2-specific antibodies may very well be detected.
Our information reveal that whereas most sufferers reply in opposition to all of the viral antigens examined, others present a marked bias to make antibodies in opposition to both proteins uncovered on the viral particle or these launched after mobile an infection. With this assay, it was doable to discriminate between sufferers and wholesome controls with 100% confidence. Analysing the response of a number of immunoglobulin isotypes to the 4 antigens together can also assist to ascertain a correlation with the severity diploma of illness. A extra detailed description of the immune responses of various sufferers to SARS-CoV-2 virus may present perception into the big selection of medical shows of COVID-19. This text is protected by copyright. All rights reserved.
Progressive use of multispectral imaging movement cytometry in numerous analysis areas
Multi-spectral imaging movement cytometry (MIFC) has develop into one of the vital highly effective applied sciences for investigating common analytics, molecular and cell biology, biotechnology, medication, and associated fields. It combines the capabilities of the morphometric and photometric evaluation of single cells and micrometer-sized particles in flux with regard to 1000’s of occasions. It has develop into the device of selection for a variety of analysis and medical purposes. By combining the options of movement cytometry and fluorescence microscopy, it provides researchers the power to couple the spatial decision of multicolour photographs of cells and organelles with the simultaneous evaluation of a lot of occasions in a single system.
![]() YLEX Expression Kit |
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FYY201-1KT | Yeastern Biotech | 1 kit | Ask for price |
![]() 293 Expression MAX-1 |
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EXP-711-11 | ACROBIOSYSTEMS | 1ml | EUR 214 |
Description: 293 Expression MAX-1 is expressed from - -. |
![]() CNGA2 Expression vector |
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60642 | BPS Bioscience | 20 µg | EUR 900 |
Description: The CNGA2 expression vector is designed to express human cyclic nucleotide-gated cation channel 2 (CNGA2) in mammalian cells. |
![]() pYLEX1 - Expression Vector |
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FYY203-5MG | Yeastern Biotech | 5mg | Ask for price |
![]() RFP expression Adenovirus, in vivo ready |
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AVP001-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made RFP expression adenovirus, provided in PBS solution. |
![]() CFP expression Adenovirus, in vivo ready |
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AVP002-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made CFP expression adenovirus, provided in PBS solution. |
![]() GFP expression Adenovirus, in vivo ready |
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AVP011-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made GFP expression adenovirus, provided in PBS solution. |
![]() YFP expression Adenovirus, in vivo ready |
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AVP012-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made YFP expression adenovirus, provided in PBS solution. |
![]() BFP expression Adenovirus, in vivo ready |
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AVP017-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made BFP expression adenovirus, provided in PBS solution. |
![]() Blunt E1 Expression Kit |
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abx098098-10rxns | Abbexa | 10 rxns | EUR 560.4 |
![]() Blunt E2 Expression Kit |
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abx098873-10rxns | Abbexa | 10 rxns | EUR 560.4 |
![]() RFP expression Adenovirus |
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AVP001 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made RFP expression adenovirus, provided in DMEM medium. |
![]() CFP expression Adenovirus |
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AVP002 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made CFP expression adenovirus, provided in DMEM medium. |
![]() GFP expression Adenovirus |
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AVP011 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made GFP expression adenovirus, provided in DMEM medium. |
![]() YFP expression Adenovirus |
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AVP012 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made YFP expression adenovirus, provided in DMEM medium. |
![]() BFP expression Adenovirus |
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AVP017 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made BFP expression adenovirus, provided in DMEM medium. |
![]() Rac1 Expression Vector Set |
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STA-454 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and G12V constitutively active mutant. |
![]() RhoA Expression Vector Set |
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STA-456 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and G14V constitutively active mutant. |
![]() h OCT4 expression Adenovirus, in vivo ready |
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AVP013-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in PBS solution for in vivo application. |
![]() h SOX2 expression Adenovirus, in vivo ready |
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AVP014-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in PBS solution for in vivo application. |
![]() Cdc42 Expression Vector Set |
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STA-455 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: Cdc42 Expression Vector Set contains 3 vectors: Cdc42 wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. |
![]() h LIN28 expression Adenovirus, in vivo ready |
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AVP015-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in PBS solution for in vivo application. |
![]() h ADA Expression Lentivirus |
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LVP923 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: ADA, containing a RFP-Blasticidin dual selection marker. |
![]() h IL6 Expression Lentivirus |
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LVP1144 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h CD4 Expression Lentivirus |
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LVP1152 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CD4, containing a RFP-Blasticidin dual selection marker. |
![]() h IL4 Expression Lentivirus |
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LVP1161 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: IL4, containing a RFP-Blasticidin dual selection marker. |
![]() h IL7 Expression Lentivirus |
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LVP1162 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker. |
![]() h KDR Expression Lentivirus |
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LVP1176 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: KDR, containing a RFP-Blasticidin dual selection marker. |
![]() h FAS Expression Lentivirus |
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LVP1181 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: FAS, containing a RFP-Blasticidin dual selection marker. |
![]() pAAV-MCS Expression Vector |
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VPK-410 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() h OCT4 expression Adenovirus |
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AVP013 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in DMEM medium. |
![]() h SOX2 expression Adenovirus |
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AVP014 | GenTarget | 1x109 IFU/ml x 50ul | EUR 418.8 |
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in DMEM medium. |
![]() h CDR1 Expression Lentivirus |
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LVP917 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CDR1, containing a RFP-Blasticidin dual selection marker. |
![]() h CD47 Expression Lentivirus |
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LVP918 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CD47, containing a RFP-Blasticidin dual selection marker. |
![]() h ESR1 Expression Lentivirus |
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LVP924 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: ESR1, containing a RFP-Blasticidin dual selection marker. |
![]() r Syn1 Expression Lentivirus |
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LVP925 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for rat target: Syn1, containing a RFP-Blasticidin dual selection marker. |
![]() h NME4 Expression Lentivirus |
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LVP932 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NME4, containing a RFP-Blasticidin dual selection marker. |
![]() h EGFR Expression Lentivirus |
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LVP1142 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: EGFR, containing a RFP-Blasticidin dual selection marker. |
![]() h NRP1 Expression Lentivirus |
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LVP1145 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h MUC1 Expression Lentivirus |
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LVP1148 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h CD8a Expression Lentivirus |
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LVP1151 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CD8a, containing a RFP-Blasticidin dual selection marker. |
![]() h PIGF Expression Lentivirus |
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LVP1154 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: PIGF, containing a RFP-Blasticidin dual selection marker. |
![]() h BRAF Expression Lentivirus |
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LVP1156 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: BRAF, containing a RFP-Blasticidin dual selection marker. |
![]() h ROS1 Expression Lentivirus |
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LVP1158 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: ROS1, containing a RFP-Blasticidin dual selection marker. |
![]() h CD3E Expression Lentivirus |
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LVP1163 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker. |
![]() h KLK3 Expression Lentivirus |
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LVP1171 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: KLK3, containing a RFP-Blasticidin dual selection marker. |
![]() h NEK6 Expression Lentivirus |
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LVP1182 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NEK6, containing a RFP-Blasticidin dual selection marker. |
![]() h NEK7 Expression Lentivirus |
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LVP1183 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NEK7, containing a RFP-Blasticidin dual selection marker. |
![]() h LIN28 expression Adenovirus |
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AVP015 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in DMEM medium. |
![]() h GPNMB Expression Lentivirus |
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LVP921 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: GPNMB, containing a RFP-Blasticidin dual selection marker. |
![]() h DECR1 Expression Lentivirus |
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LVP927 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: DECR1, containing a RFP-Blasticidin dual selection marker. |
![]() h DECR2 Expression Lentivirus |
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LVP928 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: DECR2, containing a RFP-Blasticidin dual selection marker. |
![]() h NMRK1 Expression Lentivirus |
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LVP930 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NMRK1, containing a RFP-Blasticidin dual selection marker. |
![]() h PITX3 Expression Lentivirus |
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LVP931 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: PITX3, containing a RFP-Blasticidin dual selection marker. |
![]() h HDAC1 Expression Lentivirus |
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LVP1143 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h VEGFB Expression Lentivirus |
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LVP1146 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h PARP1 Expression Lentivirus |
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LVP1149 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h IL3RA Expression Lentivirus |
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LVP1150 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: IL3RA, containing a RFP-Blasticidin dual selection marker. |
![]() h PTCH1 Expression Lentivirus |
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LVP1155 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: PTCH1, containing a RFP-Blasticidin dual selection marker. |
![]() h SART3 Expression Lentivirus |
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LVP1159 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: SART3, containing a RFP-Blasticidin dual selection marker. |
![]() h TIGIT Expression Lentivirus |
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LVP1160 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: TIGIT, containing a RFP-Blasticidin dual selection marker. |
![]() h EDNRA Expression Lentivirus |
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LVP1165 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: EDNRA containing a RFP-Blasticidin dual selection marker. |
![]() h Foxp3 Expression Lentivirus |
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LVP1172 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: Foxp3, containing a RFP-Blasticidin dual selection marker. |
![]() m RIKEN Expression Lentivirus |
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LVP1174 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for mouse target: RIKEN, containing a RFP-Blasticidin dual selection marker. |
![]() h APLP2 Expression Lentivirus |
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LVP1177 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: APLP2, containing a RFP-Blasticidin dual selection marker. |
![]() h PCSK9 Expression Lentivirus |
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LVP1178 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: PCSK9, containing a RFP-Blasticidin dual selection marker. |
![]() h NTSR1 Expression Lentivirus |
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LVP1179 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NTSR1, containing a RFP-Blasticidin dual selection marker. |
![]() pscAAV-MCS Expression Vector |
|||
VPK-430 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() H-Ras Expression Vector Set |
|||
STA-457 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: H-Ras Expression Vector Set contains 3 vectors: H-Ras wild type, T19N dominant negative mutant, and G12V constitutively active mutant. |
![]() m CTAGA1 Expression Lentivirus |
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LVP916 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for mouse target: CTAGA1, containing a RFP-Blasticidin dual selection marker. |
![]() h SKIV2L Expression Lentivirus |
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LVP919 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: SKIV2L, containing a RFP-Blasticidin dual selection marker. |
![]() h SKIV2L Expression Lentivirus |
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LVP919-GP | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: SKIV2L, containing a GFP-Puromycin dual selection marker. |
![]() h TP5313 Expression Lentivirus |
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LVP926 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: TP5313, containing a RFP-Blasticidin dual selection marker. |
![]() h ELOVL5 Expression Lentivirus |
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LVP929 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: ELOVL5, containing a RFP-Blasticidin dual selection marker. |
![]() h MAGEA3 Expression Lentivirus |
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LVP1147 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker. |
![]() h NANOS3 Expression Lentivirus |
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LVP1164 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: NANOS3, containing a RFP-Blasticidin dual selection marker. |
![]() h IL1RL1 Expression Lentivirus |
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LVP1168 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: IL1RL1, containing a RFP-Blasticidin dual selection marker. |
![]() h CTAG1B Expression Lentivirus |
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LVP1169 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CTAG1B, containing a RFP-Blasticidin dual selection marker. |
![]() h MAGEA3 Expression Lentivirus |
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LVP1170 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: MAGEA3, containing a RFP-Blasticidin dual selection marker. |
![]() h COX7A1 Expression Lentivirus |
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LVP1173 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: COX7A1, containing a RFP-Blasticidin dual selection marker. |
![]() h BCL11B Expression Lentivirus |
|||
LVP1180 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: BCL11B, containing a RFP-Blasticidin dual selection marker. |
![]() pUC57-sgRNA expression vector |
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PVT18003 | Lifescience Market | 2 ug | EUR 309.6 |
![]() BRAF, His-Tag (High Expression) |
|||
41237 | BPS Bioscience | 10 µg | EUR 375 |
Description: Human BRAF, also known as B-RAF1 and RAFB1, with 18 mutations to improve expression; S446A, S447A, I543A, I544S, I551K, Q562R, L588N, K630S, F667E, Y672S, A688R, L706S, Q709R, S713E, L716E, S720E, P722S, K723G. GenBank Accession #NM_004333, a.a. 444-723 with N-terminal His-tag, expressed in E. coli cells. MW = 33 kDa. |
![]() ANPRA/Aequorin Expression vector |
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60641 | BPS Bioscience | 20 µg | EUR 900 |
Description: The ANPRA/Aequorin expression vector is designed to co-express human atrial natriuretic peptide receptor A (ANPRA, also called natriuretic peptide receptor A/guanylate cyclase A) and jellyfish (Aequorea victoria) Aequorin in mammalian cells. |
![]() h CEACAM5 Expression Lentivirus |
|||
LVP1153 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: CEACAM5, containing a RFP-Blasticidin dual selection marker. |
![]() h TNFSF11 Expression Lentivirus |
|||
LVP1157 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: TNFSF11, containing a RFP-Blasticidin dual selection marker. |
![]() h TNFRSF1B Expression Lentivirus |
|||
LVP922 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: TNFRSF1B, containing a RFP-Blasticidin dual selection marker. |
![]() h KIAA1324 Expression Lentivirus |
|||
LVP1175 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: KIAA1324, containing a RFP-Blasticidin dual selection marker. |
![]() GFP-Rac1 Expression Vector Set |
|||
STA-450 | Cell Biolabs | 1 kit | EUR 1939.2 |
Description: GFP-Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence. |
![]() GFP-RhoA Expression Vector Set |
|||
STA-452 | Cell Biolabs | 1 kit | EUR 1939.2 |
Description: GFP-RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and Q63L constitutively active mutant. Each vector also contains a GFP reporter sequence. |
![]() h KIAA0319L Expression Lentivirus |
|||
LVP920 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for human target: KIAA0319L, containing a RFP-Blasticidin dual selection marker. |
![]() GFP-Cdc42 Expression Vector Set |
|||
STA-451 | Cell Biolabs | 1 kit | EUR 1939.2 |
Description: GFP-Cdc42 Expression Vector Set contains 3 vectors: Cdc42 wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence. |
![]() Active Rac1 Expression Vector Set |
|||
STA-458 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: Active Rac1 Expression Vector Set contains 3 vectors expressing different constitutively active mutants of Rac1: Q61L, Q61L/F37A, and Q61L/Y40C. |
![]() PhiC31 Integrase Expression Plasmid |
|||
FC200PA-1 | SBI | 10ug | EUR 496 |
![]() pCMV-GFP-LC3 Expression Vector |
|||
CBA-401 | Cell Biolabs | 100 µL | EUR 1243.2 |
Description: Expression vector contains a fusion of GFP and LC3. A separate GFP control vector is also included. |
![]() h KRAS (G12D) Expression Lentivirus |
|||
LVP1166 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for a mutant (G12D) of human target: KRAS containing a RFP-Blasticidin dual selection marker. |
![]() Tet-on circRNA Expression Vector |
|||
PVT14643 | Lifescience Market | 2 ug | EUR 843.6 |
![]() h TP53 (R175H) Expression Lentivirus |
|||
LVP1167 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made over-expression lentivirus for a mutant R175H) of human target: TP53, containing a RFP-Blasticidin dual selection marker. |
![]() pAAV-IRES-Neo Expression Vector |
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VPK-416 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() pAAV-IRES-GFP Expression Vector |
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VPK-418 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() pAAV-IRES-Bsd Expression Vector |
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VPK-419 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() PinPoint Integrase Expression Plasmid |
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PIN200A-1 | SBI | 10ug | EUR 688 |
![]() pAAV-IRES-Puro Expression Vector |
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VPK-415 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() CEACAM5 CHO Cell Line (Low Expression) |
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78704-L | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line. |
![]() Active H-Ras Expression Vector Set |
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STA-459 | Cell Biolabs | 1 kit | EUR 1765.2 |
Description: Active H-Ras Expression Vector Set contains 3 vectors expressing different constitutively active mutants of H-Ras: V12, V12S35, and V12C40. |
![]() B7-H3 CHO Cell Line (Low Expression) |
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78541-L | BPS Bioscience | 2 vials | EUR 7150 |
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types. |
![]() pAAV-IRES-Hygro Expression Vector |
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VPK-417 | Cell Biolabs | 10 µg | EUR 776.4 |
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV. |
![]() CD36 HEK293 Cell Line (High Expression) |
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78526-H | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line. |
![]() CEACAM5 CHO Cell Line (High Expression) |
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78704-H | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line. |
![]() AAV-1 Helper Free Expression System |
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VPK-410-SER1 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() AAV-2 Helper Free Expression System |
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VPK-410-SER2 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() AAV-3 Helper Free Expression System |
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VPK-410-SER3 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() AAV-4 Helper Free Expression System |
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VPK-410-SER4 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() AAV-5 Helper Free Expression System |
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VPK-410-SER5 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() AAV-6 Helper Free Expression System |
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VPK-410-SER6 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() B7-H3 CHO Cell Line (High Expression) |
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78541-H | BPS Bioscience | 2 vials | EUR 7150 |
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types. |
![]() AAV-DJ Helper Free Expression System |
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VPK-410-DJ | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. |
![]() Gryphon Retroviral Expression System I |
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ABP-RVK-10001 | Allele Biotech | 1 set | Ask for price |
Description: PRODUCT LINE DISCONTINUED. Please contact us. |
![]() Gryphon Retroviral Expression System II |
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ABP-RVK-10002 | Allele Biotech | 1 set | Ask for price |
Description: PRODUCT LINE DISCONTINUED. Please contact us. |
![]() CD7 CHO Cell Line (Medium or High Expression)-78324-H |
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78324-H | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels. |
![]() CD7 CHO Cell Line (Medium or High Expression)-78324-M |
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78324-M | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels. |
![]() CD36 HEK293 Cell Line (Medium Expression) |
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78526-M | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line. |
![]() CEACAM5 CHO Cell Line (Medium Expression) |
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78704-M | BPS Bioscience | 2 vials | EUR 7150 |
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line. |
![]() Human Myelin expression factor 2 (MYEF2) |
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1-CSB-EP015283HU | Cusabio |
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Description: Recombinant Human Myelin expression factor 2(MYEF2),partial expressed in E.coli |
![]() scAAV-1 Helper Free Expression System |
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VPK-430-SER1 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() scAAV-2 Helper Free Expression System |
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VPK-430-SER2 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() scAAV-3 Helper Free Expression System |
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VPK-430-SER3 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() scAAV-4 Helper Free Expression System |
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VPK-430-SER4 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() scAAV-5 Helper Free Expression System |
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VPK-430-SER5 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() scAAV-6 Helper Free Expression System |
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VPK-430-SER6 | Cell Biolabs | 1 kit | EUR 1486.8 |
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). |
![]() B7-H3 CHO Cell Line (Medium Expression) |
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78541-M | BPS Bioscience | 2 vials | EUR 7150 |
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types. |
![]() CD95 CHO Cell Line (Medium or High Expression)-78499-H |
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78499-H | BPS Bioscience | 2 vials | EUR 7150 |
Description: The CD95 CHO cell line is a recombinant clonal stable CHO cell line constitutively expressing full-length human CD95 receptor (accession number: NM_000043.3). Surface expression of human CD95 was confirmed by flow cytometry. Each clonal cell line was selected for different levels of CD95 expression (High or Medium) to mimic varying CD95 expression levels in cancer cells. |
![]() CD95 CHO Cell Line (Medium or High Expression)-78499-M |
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78499-M | BPS Bioscience | 2 vials | EUR 7150 |
Description: The CD95 CHO cell line is a recombinant clonal stable CHO cell line constitutively expressing full-length human CD95 receptor (accession number: NM_000043.3). Surface expression of human CD95 was confirmed by flow cytometry. Each clonal cell line was selected for different levels of CD95 expression (High or Medium) to mimic varying CD95 expression levels in cancer cells. |
![]() Protein Limb Expression 1 (LIX1) Antibody |
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20-abx318393 | Abbexa |
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![]() Protein Limb Expression 1 (LIX1) Antibody |
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abx146234-100ug | Abbexa | 100 ug | EUR 469.2 |
![]() Protein Limb Expression 1 (LIX1) Antibody |
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abx025913-400ul | Abbexa | 400 ul | EUR 627.6 |
![]() Protein Limb Expression 1 (LIX1) Antibody |
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abx025913-80l | Abbexa | 80 µl | EUR 343.2 |
This supplies the chance to visually verify findings and gather novel information that might in any other case be harder to acquire. This has led many researchers to design modern assays to realize new perception into essential analysis questions. So far, it has been efficiently used to check cell morphology, floor and nuclear protein co-localization, protein-protein interactions, cell signaling, cell cycle, cell dying, and cytotoxicity, intracellular calcium, drug uptake, pathogen internalization, and different purposes. Herein we describe a number of the current advances within the discipline of multiparametric imaging movement cytometry strategies in numerous analysis areas.