Efficacy and security of anti-PD-1 monoclonal antibody in superior hepatocellular carcinoma after TACE mixed with TKI remedy

Stability Evaluation of FDA Authorised Ramucirumab Monoclonal Antibody; Validated SE-HPLC Technique for Degradation Sample Analysis
A MONOCLONAL ANTI-CGRP ANTIBODY DECREASES STRESS-INDUCED COLONIC HYPERSENSITIVITY
BACKGROUND: Irritable bowel syndrome (IBS) is a brain-gut dysfunction characterised by stomach ache and altered bowel habits. Whereas the etiology of IBS stays unclear, stress in maturity or in youth, has been proven to be a big issue within the growth of IBS symptomatology. Proof means that aberrant calcitonin-gene associated peptide (CGRP) signaling could also be concerned in afferent sensitization and visceral organ hypersensitivity. Right here, we make the most of a monoclonal anti-CGRP F(ab’)2 fragment antibody to check the speculation that inhibition of peripheral CGRP signaling reverses colonic hypersensitivity induced by both persistent grownup stress or youth stress.
METHODS: A cohort of grownup male rats had been uncovered to repeated water avoidance stress (WAS). Moreover, a second cohort consisting of feminine rats had been uncovered to a female-specific neonatal odor-attachment studying paradigm of unpredictable youth stress (ELS). Colonic sensitivity was then assessed in grownup animals through behavioral responses to colorectal distension (CRD). To be able to analyze spinal nociceptive signaling in response to CRD, dorsal horn extracellular signal-regulated kinase (ERK1/2) phosphorylation (pERK), was measured through immunohistochemistry.
RESULTS: Repeated psychological stress in maturity or unpredictable stress in youth induced colonic hypersensitivity and enhanced evoked ERK1/2 phosphorylation within the spinal twine following CRD in rats. These phenotypes had been reversed by administration of a monoclonal anti-CGRP F(ab’)2 fragment antibody.
CONCLUSIONS: Stress-induced adjustments in visceral sensitivity and spinal nociceptive signaling had been reversed by inhibition of peripheral CGRP signaling, suggesting a outstanding position for CGRP in central sensitization and the event of stress-induced visceral hypersensitivity. Significance Assertion Concentrating on peripheral CGRP with a monoclonal anti-CGRP F(ab’)2 fragment antibody lowered central sensitization and attenuated colonic hypersensitivity induced by both persistent grownup stress or youth stress. CGRP concentrating on antibodies are accepted for migraine prevention and our outcomes counsel that concentrating on CGRP might present a novel remedy technique for IBS-related stress-induced visceral ache.
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-b-48Tests | Reddot Biotech | 48 Tests | EUR 555 |
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-b-96Tests | Reddot Biotech | 96 Tests | EUR 771 |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Eq-48Tests | Reddot Biotech | 48 Tests | EUR 566 |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Eq-96Tests | Reddot Biotech | 96 Tests | EUR 787 |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 393 |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 541 |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-p-48Tests | Reddot Biotech | 48 Tests | EUR 555 |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-p-96Tests | Reddot Biotech | 96 Tests | EUR 771 |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 511 |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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RD-MPO-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 709 |
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-b-48T | DL Develop | 48T | EUR 547 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-b-96T | DL Develop | 96T | EUR 715 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Eq-48T | DL Develop | 48T | EUR 556 |
Description: A sandwich quantitative ELISA assay kit for detection of Equine Myeloperoxidase (MPO) in samples from serum, plasma or other biological fluids. |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Eq-96T | DL Develop | 96T | EUR 728 |
Description: A sandwich quantitative ELISA assay kit for detection of Equine Myeloperoxidase (MPO) in samples from serum, plasma or other biological fluids. |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Hu-48T | DL Develop | 48T | EUR 404 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Hu-96T | DL Develop | 96T | EUR 518 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-p-48T | DL Develop | 48T | EUR 547 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-p-96T | DL Develop | 96T | EUR 715 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Ra-48T | DL Develop | 48T | EUR 508 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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DLR-MPO-Ra-96T | DL Develop | 96T | EUR 661 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Myeloperoxidase (MPO) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-b-48Tests | Reddot Biotech | 48 Tests | EUR 580 |
![]() Bovine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-b-96Tests | Reddot Biotech | 96 Tests | EUR 807 |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Eq-48Tests | Reddot Biotech | 48 Tests | EUR 591 |
![]() Equine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Eq-96Tests | Reddot Biotech | 96 Tests | EUR 823 |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 411 |
![]() Human Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 565 |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-p-48Tests | Reddot Biotech | 48 Tests | EUR 580 |
![]() Porcine Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-p-96Tests | Reddot Biotech | 96 Tests | EUR 807 |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 534 |
![]() Rat Myeloperoxidase (MPO) ELISA Kit |
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RDR-MPO-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 742 |
![]() Mouse Monoclonal Anti-Human Myeloperoxidase (MPO) IgG |
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MPO11-M | Alpha Diagnostics | 100 ul | EUR 482 |
![]() Anti-Myeloperoxidase/MPO Antibody |
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PA1054 | BosterBio | 100ug/vial | EUR 334 |
![]() Anti-Myeloperoxidase/MPO Antibody |
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PB9057 | BosterBio | 100ug/vial | EUR 334 |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine) |
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4-MAA601Bo21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO) |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human) |
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4-MAA601Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO) |
![]() Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2b* |
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V100095 | AAT Bioquest | 50 ug | EUR 306 |
![]() Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2b* |
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V100096 | AAT Bioquest | 1 mg | EUR 741 |
![]() Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2a* |
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V100100 | AAT Bioquest | 50 ug | EUR 306 |
![]() Anti-Myeloperoxidase (MPO) antibody *Mouse anti-human, monoclonal IgG2a* |
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V100101 | AAT Bioquest | 1 mg | EUR 741 |
![]() anti-MPO(Myeloperoxidase) (1A1) |
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LF-MA0154 | Abfrontier | 100 ul | EUR 334 |
Description: Mouse monoclonal to MPA(Myeloperoxidase) |
![]() Myeloperoxidase (MPO) Antibody |
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20-abx130166 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx121646 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx110017 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx323504 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx101226 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx101227 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx101228 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx101229 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx132186 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx132294 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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abx139760-01mg | Abbexa | 0.1 mg | EUR 411 |
![]() Myeloperoxidase (MPO) Antibody |
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20-abx135718 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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abx011219-100ul | Abbexa | 100 ul | EUR 411 |
![]() Myeloperoxidase (MPO) Antibody |
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abx026324-400ul | Abbexa | 400 ul | EUR 523 |
![]() Myeloperoxidase (MPO) Antibody |
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abx026324-80l | Abbexa | 80 µl | EUR 286 |
![]() Myeloperoxidase (MPO) Antibody |
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abx027178-400ul | Abbexa | 400 ul | EUR 523 |
![]() Myeloperoxidase (MPO) Antibody |
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abx027178-80l | Abbexa | 80 µl | EUR 286 |
![]() Myeloperoxidase (MPO) Antibody |
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abx027964-400ul | Abbexa | 400 ul | EUR 523 |
![]() Myeloperoxidase (MPO) Antibody |
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abx027964-80l | Abbexa | 80 µl | EUR 286 |
![]() Myeloperoxidase (MPO) Antibody |
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abx020792-1mg | Abbexa | 1 mg | EUR 801 |
![]() Myeloperoxidase (MPO) Antibody |
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abx020793-1mg | Abbexa | 1 mg | EUR 843 |
![]() Myeloperoxidase (MPO) Antibody |
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abx020795-1mg | Abbexa | 1 mg | EUR 843 |
![]() Myeloperoxidase (MPO) Antibody |
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abx020797-1mg | Abbexa | 1 mg | EUR 843 |
![]() Myeloperoxidase (MPO) Antibody |
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abx020799-02mg | Abbexa | 0.2 mg | EUR 1219 |
![]() Myeloperoxidase (MPO) Antibody |
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abx022717-1ml | Abbexa | 1 ml | EUR 411 |
![]() myeloperoxidase (MPO) Antibody |
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abx433002-200ul | Abbexa | 200 ul | EUR 384 |
![]() Myeloperoxidase (MPO) Antibody |
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abx235285-100ug | Abbexa | 100 ug | EUR 551 |
![]() Myeloperoxidase (MPO) Antibody |
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abx235286-100ug | Abbexa | 100 ug | EUR 551 |
![]() Myeloperoxidase (MPO) Antibody |
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20-abx212231 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx210157 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx177656 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx177657 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx173656 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx173657 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx173658 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx173659 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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20-abx327714 | Abbexa |
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![]() Myeloperoxidase (MPO) Antibody |
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3831-100 | Biovision | EUR 316 |
![]() Myeloperoxidase (MPO) Antibody |
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3831-30T | Biovision | EUR 146 |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), APC |
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4-MAA601Bo21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with APC. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), Biotinylated |
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4-MAA601Bo21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with Biotin. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), Cy3 |
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4-MAA601Bo21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with Cy3. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), FITC |
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4-MAA601Bo21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with FITC. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), HRP |
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4-MAA601Bo21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with HRP. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), PE |
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4-MAA601Bo21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with PE. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), APC |
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4-MAA601Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with APC. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), Biotinylated |
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4-MAA601Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with Biotin. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), Cy3 |
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4-MAA601Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with Cy3. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), FITC |
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4-MAA601Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with FITC. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), HRP |
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4-MAA601Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with HRP. |
![]() Myeloperoxidase (MPO) Monoclonal Antibody (Human), PE |
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4-MAA601Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with PE. |
![]() Myeloperoxidase (MPO) Polyclonal Antibody (Mouse) |
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4-PAA601Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Myeloperoxidase (MPO) |