Inflammatory complications of CGRP monoclonal antibodies: a case series

Background:¬†Calcitonin gene-related peptide (CGRP) is expressed all through the physique and is a recognized mediator of migraine, exerting this organic impact by activation of trigeminovascular, meningeal and related neuronal pathways positioned in shut proximity to the central nervous system. Monoclonal antibodies (mAb) concentrating on the CGRP pathway are an efficient new preventive therapy for migraine, […]

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses

Psychotic issues are widespread and disabling psychological circumstances. The relative significance of immune-related mechanisms in psychotic issues stays topic of debate. Right here, we current a large-scale retrospective research of blood and cerebrospinal fluid (CSF) immune cell profiles of psychosis spectrum sufferers. We carried out primary CSF evaluation and multi-dimensional movement cytometry of CSF and […]